IMMUNOLOGICAL MEMORY IN MICE
نویسندگان
چکیده
منابع مشابه
Immunological Memory in Mice
Plaque forming cells (PFC) of different immunoglobulin classes producing antibodies against sheep erythrocytes were separated according to their buoyant densities by means of equilibrium centrifugation in a stepwise BSA gradient. In the period of 7-10 days after immunization gammaM PFC are markedly enriched in fractions of low density and relatively depleted in fractions of high density. The di...
متن کاملCharacteristics of Immunological Memory in Mice
The kinetics of the generation of primed IgM and IgG antibody-forming cell precursors, and of helper T-cell populations, were analyzed in mice whose primary responses to high and low doses of SRBC were arrested at intervals by the immunosuppressive agents cyclophosphamide monohydrate and specific antibody. The extent to which immunological memory was established in these animals before blockade...
متن کاملQuantitative Studies of the Adoptive Immunological Memory in Mice
Antibody-forming cells suspended from a mouse spleen and transferred to intact animals of the same genotype face a barrier which severely affects their capacity to implant and/or to function. This phenomenon was quantitatively studied in a model system which, utilizing the immunogenic properties of human serum albumin in mice, allows the secondary response of the transferred cells to be followe...
متن کاملImmunological Memory in Vitro
The immune responses to sheep erythrocytes of mouse spleen cell suspensions from immune and nonimmune donors were compared in vitro. In vivo immunity was only transiently reflected in vitro, and 8 wk after in vivo immunization the responses of cultures from immunized and nonimmunized mice were virtually identical. There appeared to be two mechanisms for an antibody response to sheep erythrocyte...
متن کاملImmunological memory in humans.
Specificity and memory are the defining characteristics of adaptive immune responses. Vaccines are predicated on the existence of immune memory, and the robustness of immune memory is a primary determinant of vaccine efficacy. How is immune memory maintained? Much progress has been made in this area over the past several years, and new human studies have added key insights into the longevity of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1970
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.131.6.1093